PI3K inhibitor X ( XL-147 analog )

Catalog No. M16833 CAS No. 956958-53-5

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Product Name

PI3K inhibitor X
Note

Research use only, not for human use.
Brief Description

PI3K inhibitor X (XL-147 analog) is a derivative of XL147 that acts as a reversible inhibitor.
Description

PI3K inhibitor X (XL-147 analog) is a derivative of XL147 that acts as a reversible inhibitor of class I PI3Ks with IC50 of 39, 36, 23 and 383 nM for p110α, δ, γ and β respectively; Compound 147 in patent WO2012006552A1.
Synonyms

XL-147 analog
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

DNA-PK;PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ
Research Area

Cancer
Indication

——

CAS Number

956958-53-5
Formula Weight

448.52
Molecular Formula

C21H16N6O2S2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=S(C1=CC=C(C)C=C1)(NC2=NC3=CC=CC=C3N=C2NC4=CC5=NSN=C5C=C4)=O
Chemical Name

Benzenesulfonamide, N-[3-(2,1,3-benzothiadiazol-5-ylamino)-2-quinoxalinyl]-4-methyl-

1. Carlos L. Arteaga, et al. Combinations of kinase inhibitors for the treatment of cancer. WO 2012006552 A1.

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